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Related Experiment Videos

The premenstrual syndrome.

K Muse1

  • 1University of Kentucky, Division of Reproductive Endocrinology, Chandler Medical Center, Lexington 40536-0084.

Current Opinion in Obstetrics & Gynecology
|December 1, 1991
PubMed
Summary
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Recent premenstrual syndrome (PMS) research shows diagnosis may improve with the Calendar of Premenstrual Experiences. Progesterone therapy showed no benefit, but eliminating menstrual cycles effectively treats PMS.

Area of Science:

  • Reproductive endocrinology
  • Gynecology
  • Psychiatry

Background:

  • Premenstrual syndrome (PMS) diagnosis and treatment remain areas of active research.
  • Recent advancements have been made in understanding PMS.
  • The role of sex steroids in PMS is under scrutiny.

Purpose of the Study:

  • To review recent progress in premenstrual syndrome (PMS) research.
  • To discuss the potential of the Calendar of Premenstrual Experiences for diagnosis.
  • To evaluate the efficacy of sex steroid manipulation in PMS treatment.

Main Methods:

  • Review of recent scientific literature on PMS.
  • Analysis of a large, well-designed study on progesterone supplementation.
  • Evaluation of outcomes from surgical or medical elimination of menstrual cyclicity.

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Main Results:

  • The Calendar of Premenstrual Experiences may lead to more uniform PMS diagnosis.
  • Progesterone supplementation was found to be no more effective than placebo.
  • Eliminating menstrual cyclicity effectively treats PMS, with sex steroid replacement not inducing symptom recurrence.

Conclusions:

  • PMS pathophysiology remains unclear, potentially involving sex steroids, nutrition, and the adrenal axis.
  • Eliminating menstrual cyclicity is a viable long-term PMS treatment.
  • Further research into PMS etiology is warranted.