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Updated: Jul 8, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

Effect of systemic blood pressure on microcollateral circulation evaluated by real-time contrast echocardiography

Fuminobu Ishikura1, Ayako Miki, Akiko Iwata

  • 1School of Allied Health Sciences, Osaka University, Faculty of Medicine, Osaka, Japan. ishikura@sahs.med.osaka-u.ac.jp

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|January 12, 2008
PubMed

Insights

Systemic blood pressure significantly impacts myocardial blood flow during acute myocardial infarction. Maintaining optimal blood pressure is crucial for preserving heart tissue by enhancing collateral circulation, thus reducing infarct size.

Area of Science:

  • Cardiovascular Research
  • Myocardial Infarction Pathophysiology
  • Hemodynamics

Background:

  • Collateral circulation significantly influences infarct size in acute myocardial infarction.
  • Managing systemic blood pressure (sBP) to optimize collateral flow remains challenging.
  • Understanding sBP's role is key to improving treatment strategies.

Purpose of the Study:

  • To investigate the impact of systemic blood pressure on collateral circulation's ability to rescue ischemic myocardium.
  • To quantify the relationship between sBP and myocardial blood flow in an acute myocardial infarction model.

Main Methods:

  • Utilized real-time myocardial contrast echocardiography in open-chest dogs following coronary artery occlusion.
  • Calculated myocardial blood flow (CBF) and evaluated defect size (%DS) under varying sBP induced by vasoactive agents.
  • Employed custom offline software for quantitative analysis of echocardiographic images.

Main Results:

  • Lower sBP correlated with increased defect size and decreased CBF.
  • Higher sBP showed decreased defect size and increased CBF.
  • Excessively high sBP led to increased defect size and reduced CBF, indicating a non-linear relationship.

Conclusions:

  • Real-time myocardial contrast echocardiography provides quantitative collateral perfusion assessment.
  • This method is vital for guiding treatment and management strategies in acute myocardial infarction.
  • Optimizing systemic blood pressure is critical for maximizing the benefits of collateral circulation.
Abstract

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