Related Experiment Video
Updated: Jul 8, 2026

A Murine Model of Carotid Aneurysm Formation
Published on: September 9, 2025
Rapid development of a de novo intracranial aneurysm following carotid occlusion
Y Y Wang1, J V Rosenfeld, S M Lyon
1Department of Neurosurgery, The Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
Insights
Carotid occlusion can lead to new aneurysms forming years later. This case shows rapid de novo aneurysm development, highlighting the need for diligent radiological surveillance after the procedure.
Area of Science:
- Vascular Surgery
- Neurology
- Radiology
Background:
- Carotid occlusion is a treatment for intracranial aneurysms.
- A known complication is de novo aneurysm formation due to altered hemodynamics.
- Current surveillance protocols are not formalized.
Observation:
- A patient developed a posterior communicating artery aneurysm rapidly after contralateral carotid occlusion.
- The indication for occlusion was a traumatic intracavernous aneurysm.
- This occurred much sooner than the typical years-long timeframe.
Findings:
- De novo aneurysm formation can occur rapidly after carotid occlusion.
- Hemodynamic changes in the circle of Willis may accelerate this process.
- This challenges the established long-term timeline for such complications.
Implications:
- Formalized radiological surveillance is crucial following carotid occlusion.
- Early detection of de novo aneurysms can prevent rupture.
- This case underscores the importance of individualized patient monitoring.
Abstract:
Carotid occlusion is a therapeutic intervention for specific intracranial vascular conditions, including giant, traumatic and intracavernous aneurysms. The long-term complications include de novo aneurysm formation at a distant site due to hemodynamic changes in the circle of Willis. The time frame for de novo aneurysm formation has been described in years with a mean of 9.6 years. There is no formalised radiological surveillance program following carotid occlusion. We describe the rapid development of a de novo posterior communicating artery aneurysm following contralateral carotid occlusion for a traumatic intracavernous aneurysm and suggest the need for a formalised radiological follow-up program following carotid occlusion.
Related Concept Videos
The Arch of Aorta
Encircling the heart, the coronary arteries form a ring-like structure before...
Transient Ischemic Attack l: Introduction
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Arteries of the Head and Neck
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
Ischemic Stroke ll: Pathophysiology
Aneurysm III: Interprofessional Care
