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Published on: October 21, 2017
Methasteron-associated cholestatic liver injury: clinicopathologic findings in 5 cases
Neeral L Shah1, Isabel Zacharias, Urmila Khettry
1Department of Gastroenterology, Lahey Clinic Medical Center, Burlington, Massachusetts 01805, USA.
Background & Aims:
Methasteron is a nutritional supplement used to increase weight or accelerate the build-up of muscle mass. The aim of this study was to describe 5 cases of hepatotoxicity in patients using methasteron seen at tertiary-care medical centers.
Methods:
A case report design was used.
Results:
Five previously healthy patients who used methasteron developed jaundice 2 weeks after discontinuation; they presented to a tertiary-care medical center 2 weeks later. Within another 2 to 3 weeks, bilirubin levels peaked. About 12 weeks after initial presentation, all cases resolved with no identifiable residual hepatic dysfunction.
Conclusions:
Methasteron use can result in severe hepatotoxicity. Liver failure can worsen after initial presentation, especially within 2 weeks. With close observation and supportive care, acute hepatic injury should resolve.
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