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Published on: October 28, 2022
Ligand-binding prediction for ErbB2, a key molecule in the pathogenesis of leprosy
1Department of Clinical Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. wviroj@yahoo.com
Background And Aims:
Mycobacterium leprae is an obligate intracellular pathogen. Ligand-binding is an important factor in the success of chemoprevention and chemotherapy. A new drug that can inhibit M. leprae binding to and activation of, ErbB2 and Erk1/2 in primary Schwann cells is the new therapeutic option. However, the ligand-binding pattern of ErbB2 has never been clarified.
Methods:
In this work, the author performed a ligand-binding prediction for ErbB2 using a new bioinformatics tool.
Results:
According to this study, nine strong possible ligands can be identified.
Conclusion:
These sites can be useful for further drug-development studies.
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