Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cryptococcal Meningitis

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

Candidiasis

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...

Fungal Group Zygomycota

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Antifungal Agents

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Contrasting Case-Control and Normative Reference Approaches to Capture Clinically Relevant Structural Brain Abnormalities in Patients With First-Episode Psychosis Who Are Antipsychotic Naive.

JAMA psychiatry·2022

Same author

Culturally modified olfactory test adapted to East-Turkey: A comparison with Sniffin' Sticks.

International journal of clinical practice·2021

Same author

Assessment of Bone Conduction Thresholds After Surgical Treatment in Patients with Labyrinthine Fistula.

Turkish archives of otorhinolaryngology·2018

Same author

Neutrophil-Lymphocyte Ratio as a Prognostic Factor in Laryngeal Carcinoma.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2018

Same author

The protective effect of intratympanic dexamethasone on streptomycin ototoxicity in rats.

Ear, nose, & throat journal·2017

Same author

Bacteriological profile in conjunctival, lacrimal sac, and nasal specimens and conjunctival normalization time following external, endoscopic, and transcanalicular multidiode laser dacryocystorhinostomy.

Arquivos brasileiros de oftalmologia·2016

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Intradermal Inoculation of Mycobacterium avium in the Mouse Ear

Intradermal Inoculation of Mycobacterium avium in the Mouse Ear

Published on: July 3, 2025

Auricular mucormycosis: a case report.

M Faruk Oktay¹, Ibrahim Askar, Nihal Kilinç

¹Department of Otolaryngology, Medicine Faculty of Dicle University, Diyarbakir, Turkey. farukoktay@hotmail.com

Kulak Burun Bogaz Ihtisas Dergisi : KBB = Journal of Ear, Nose, and Throat

|January 12, 2008

Summary

A rare fungal infection, mucormycosis, rapidly progressed in a diabetic ketoacidosis patient, causing extensive tissue necrosis and facial paralysis. Despite treatment, the patient succumbed to the fulminant infection.

Related Experiment Videos

Last Updated: Jul 8, 2026

Intradermal Inoculation of Mycobacterium avium in the Mouse Ear

Intradermal Inoculation of Mycobacterium avium in the Mouse Ear

Published on: July 3, 2025

Area of Science:

Mycology
Infectious Diseases
Dermatology

Background:

Mucormycosis is a severe fungal infection primarily affecting immunocompromised individuals.
Risk factors include diabetes mellitus, blood disorders, and immunosuppressive therapies.
Early diagnosis and intervention are critical for managing this fulminant disease.

Observation:

A 17-year-old female with diabetic ketoacidosis presented with a necrotic, black lesion on the auricle and external ear canal.
Physical examination revealed extensive necrosis of the ear structures and surrounding skin, accompanied by facial paralysis.
Histopathology confirmed the presence of nonseptate hyphae, indicative of mucormycosis.

Findings:

The patient had a fulminant presentation of mucormycosis, likely exacerbated by diabetic ketoacidosis.
Despite surgical debridement and empirical treatment with amphotericin B, the infection proved fatal.
The case highlights the aggressive nature of mucormycosis in severely immunocompromised hosts.

Implications:

This case underscores the critical need for prompt recognition and aggressive management of mucormycosis in at-risk populations.
Diabetic ketoacidosis represents a significant risk factor that can accelerate disease progression.
Further research into optimal treatment strategies for invasive fungal infections in immunocompromised patients is warranted.