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Related Concept Videos

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
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Drug Therapy01:28

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Antianxiety Medications

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Updated: Jul 8, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

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SSRI Reduction of Nonparaphilic Sexual Addiction.

J L Elmore1

  • 1Coastal Empire Community Mental Health Center, Beaufort, SC, USA.

CNS Spectrums
|January 12, 2008
PubMed
Summary

Selective serotonin reuptake inhibitors effectively treated nonparaphilic sexual addiction (NPSA) symptoms in two patients. These findings suggest NPSA may respond to mood and obsessive-compulsive disorder treatments.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Nonparaphilic sexual addiction (NPSA) is a condition characterized by compulsive sexual behavior not linked to specific paraphilias.
  • NPSA frequently co-occurs with other psychiatric conditions, including depression and anxiety disorders.
  • Understanding the neurobiological underpinnings of NPSA is crucial for effective treatment strategies.

Purpose of the Study:

  • To present two case studies of NPSA with comorbid psychiatric disorders.
  • To explore the potential efficacy of selective serotonin reuptake inhibitors (SSRIs) in managing NPSA symptoms.
  • To discuss the differential diagnosis and etiological considerations for NPSA.

Main Methods:

  • Case report methodology detailing two individuals diagnosed with NPSA.

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  • Pharmacological intervention utilizing SSRIs as a primary treatment modality.
  • Clinical assessment of psychiatric comorbidities and symptom severity before and during treatment.

    • Main Results:

    • Significant reduction in NPSA symptoms was observed in both cases following SSRI treatment.
    • Comorbid depressive and other psychiatric symptoms also showed improvement.
    • The findings support the role of serotonergic pathways in the modulation of sexual behavior.

    Conclusions:

    • SSRI treatment appears to be a viable therapeutic option for NPSA, particularly when associated with mood or obsessive-compulsive spectrum disorders.
    • Further research is warranted to elucidate the precise mechanisms underlying NPSA and its response to SSRIs.
    • These cases highlight the importance of addressing comorbid conditions in the comprehensive management of NPSA.