[An immunological study of endogenous uveitis: changes in peripheral blood T-cell subsets and their transformation...

Dynamic changes of peripheral blood T-cell subsets and their transformation rate were studied in 77 cases of EU. The results showed that the percentages of T3+ and T4+ cells, and the T4+/T8+ ratio decreased, while the percentage of T8+ cells increased, and the T-cell transformation rate was significantly lowered. The immunofunctional changes in chronic anterior uveitis and pan-uveitis were particularly remarkable. The findings indicated that abnormal T-cell subsets and the reduced cell-mediated immunofunction played an important role in the pathogenesis of EU.