Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>In vitro</i> and <i>in silico</i> analysis of <i>L. donovani</i> enoyl acyl carrier protein reductase - A possible drug target.

Journal of biomolecular structure & dynamics·2020
Same author

Harnessing Computational Biology for Exact Linear B-Cell Epitope Prediction: A Novel Amino Acid Composition-Based Feature Descriptor.

Omics : a journal of integrative biology·2015
Same author

Fuzzy logic for personalized healthcare and diagnostics: FuzzyApp--a fuzzy logic based allergen-protein predictor.

Omics : a journal of integrative biology·2014
Same author

APSLAP: an adaptive boosting technique for predicting subcellular localization of apoptosis protein.

Acta biotheoretica·2013
Same author

The Arabidopsis stress responsive gene database.

International journal of plant genomics·2013
Same author

SCLAP: an adaptive boosting method for predicting subchloroplast localization of plant proteins.

Omics : a journal of integrative biology·2013

Related Experiment Video

Updated: Jul 8, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

An automated protein annotation filter for integrating web-based annotation tools.

Vijayakumar Saravanan1, Primanayagam Shanmughavel

  • 1DBT Bioinformatics Facility, Department of Bioinformatics, Bharathiar University, Coimbatore - 641046, Tamil Nadu, India.

Bioinformation
|January 12, 2008
PubMed
Summary

Automated protein annotation filters streamline sequence analysis. APAF enhances protein function prediction by enabling parallel processing, overcoming web tool limitations.

Keywords:
integrated toolprotein annotation

More Related Videos

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
10:40

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

Related Experiment Videos

Last Updated: Jul 8, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
10:40

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Web-based tools are common for protein function prediction from sequence data.
  • Current tools face limitations in parallel processing for multiple sequence queries due to functional programming constraints.

Purpose of the Study:

  • To develop an automated protein annotation filter (APAF).
  • To overcome limitations in parallel processing for web-based protein annotation tools.

Main Methods:

  • Development of an integrated approach for protein annotation.
  • Implementation of an automated filter for enhanced processing.

Main Results:

  • APAF facilitates parallel processing of protein sequences.
  • Overcomes functional programming constraints in web-based annotation tools.

Conclusions:

  • APAF offers an improved solution for protein function prediction.
  • The automated filter enhances the efficiency of large-scale sequence analysis.