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The effect of the type of intraperitoneally implanted prosthetic mesh on the systemic inflammatory response

G Chatzimavroudis1, I Koutelidakis, B Papaziogas

  • 12nd Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. gchatzimav@yahoo.gr

Hernia : the Journal of Hernias and Abdominal Wall Surgery
|January 12, 2008
PubMed
Abstract

Insights

Intraperitoneal implantation of polypropylene mesh, including coated and composite types, triggers a mild systemic inflammatory response. No significant differences in inflammatory markers were found between the different mesh types in rabbits.

Area of Science:

  • Surgical innovation
  • Biomaterials science
  • Immunology

Background:

  • Abdominal wall defect repair often involves synthetic mesh prosthetics.
  • Understanding the host's inflammatory response to different mesh materials is crucial for patient outcomes.
  • Polypropylene mesh is widely used, but variations exist in coatings and composite structures.

Purpose of the Study:

  • To compare the systemic inflammatory response following intraperitoneal implantation of three distinct polypropylene mesh types.
  • To evaluate differences in white blood cell count (WBC), tumor necrosis factor-alpha (TNF-alpha), and malondialdehyde (MDA) levels.

Main Methods:

  • Thirty-two rabbits underwent midline laparotomy for intraperitoneal mesh placement (polypropylene, titanium-coated polypropylene, or composite polypropylene/e-PTFE) or a sham operation.
  • Blood samples were collected preoperatively and at multiple time points (6, 24, 48, 168 hours) post-surgery.
  • Systemic inflammatory markers including WBC, TNF-alpha, and MDA were quantified.

Main Results:

  • All mesh implantation groups showed statistically significant elevations in WBC, TNF-alpha, and MDA at 6, 24, and 48 hours postoperatively.
  • No significant differences in these inflammatory markers were detected among the three different mesh types.
  • All mesh groups exhibited significantly higher WBC and TNF-alpha levels compared to the sham group at 24 hours.

Conclusions:

  • Intraperitoneal implantation of polypropylene mesh, regardless of its type (coated or composite), induces a mild systemic inflammatory response.
  • The type of polypropylene mesh used does not appear to significantly alter the systemic inflammatory reaction in this rabbit model.

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