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Reye's syndrome in Bangalore.

D G Benakappa¹, S Das, S K Shankar

¹Indira Gandhi Institute for Child Health, Bangalore.

Indian Journal of Pediatrics

|November 1, 1991

Summary

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Reye's syndrome cases in Bangalore predominantly affected young children in winter, clustering in poorer areas. Despite suggestive clinical signs, aspirin and varicella were not linked, and viral tests were negative, with a high mortality rate.

Area of Science:

Pediatrics
Epidemiology
Hepatology

Background:

Reye's syndrome is a severe condition affecting children and teenagers.
Understanding its epidemiology and risk factors is crucial for prevention and management.

Purpose of the Study:

To investigate the clinical, biochemical, and epidemiological features of Reye's syndrome cases.
To identify potential preceding factors and understand the disease's pattern in Bangalore.

Main Methods:

Retrospective analysis of 124 Reye's syndrome cases admitted to Vanivilas Children's Hospital.
Collection of clinical, biochemical, and epidemiological data.
Histopathological evaluation of 104 liver biopsy specimens and virological studies.

Main Results:

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The median age of affected children was five years, with no sex predilection.
Reye's syndrome cases peaked in winter months and were concentrated in congested, low socio-economic areas.
Aspirin and varicella infections were not identified as preceding factors; influenza and arbovirus studies were negative.
Clinical and biochemical findings were consistent with Reye's syndrome, and mortality was high at 78%.

Conclusions:

Reye's syndrome in Bangalore presented with specific demographic and seasonal patterns.
The study did not establish links to aspirin or varicella, highlighting the need for further research into etiology.
The high mortality rate underscores the severity of the condition and the importance of early diagnosis and supportive care.