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Multiple risk factor clustering and risk of hypertension in the Mongolian ethnic population of China

Chang-Qing Ying1, Song-Bin Fu, Qun Xu

  • 1Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, Heilongjiang, China.

Biomedical and Environmental Sciences : BES
|January 15, 2008
PubMed

Insights

Clustering of overweight, alcohol consumption, and renin gene I/D polymorphism significantly increases essential hypertension risk. Accumulating these factors sharply elevates hypertension risk in the Mongolian population.

Area of Science:

  • Cardiovascular Research
  • Genetics and Epidemiology
  • Public Health

Background:

  • Essential hypertension (EH) is a multifactorial condition influenced by environmental and genetic factors.
  • Understanding the combined impact of these risk factors is crucial for targeted prevention strategies.
  • The renin gene insertion/deletion (I/D) polymorphism is a potential genetic marker for hypertension risk.

Purpose of the Study:

  • To investigate whether the clustering of environmental and genetic risk factors increases the risk of essential hypertension (EH).
  • To determine if the accumulation of risk factors influences blood pressure levels in normotensive individuals.

Main Methods:

  • A case-control study involving 501 unrelated individuals of Mongolian ethnicity (243 hypertensives, 258 normotensives).
  • Data collection included questionnaires and blood specimen analysis.
  • Renin gene I/D polymorphism was genotyped using PCR and polyacrylamide gel electrophoresis.

Main Results:

  • Overweight, alcohol consumption, and renin gene I/D polymorphism were identified as significant risk factors for EH (P<0.05).
  • The odds ratios for EH increased with the number of risk factors: 2.39 for one, 5.03 for two, and 6.09 for three.
  • In normotensives, mean blood pressure increased with the accumulation of risk factors, though differences were not statistically significant across blood pressure levels.

Conclusions:

  • Overweight, alcohol consumption, and renin gene I/D polymorphism are confirmed risk factors for EH in the Mongolian population in China.
  • The cumulative effect of these risk factors leads to a substantial increase in the risk of developing essential hypertension.
Abstract

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