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Spondyloarthritis: a strong predictor of early coronary artery bypass grafting

I Hollan1, K Saatvedt, S M Almdahl

  • 1The Feiring Heart Clinic AS, Feiring, Norway. i-hollan@online.no

Scandinavian Journal of Rheumatology
|January 15, 2008
PubMed

Insights

Patients with spondyloarthritis (an inflammatory condition) experienced their first coronary artery bypass grafting (CABG) significantly earlier than those without the condition. This suggests spondyloarthritis may accelerate coronary artery disease.

Area of Science:

  • Cardiology
  • Rheumatology
  • Immunology

Background:

  • Spondyloarthritides are a group of inflammatory diseases affecting the spine and joints.
  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • The relationship between spondyloarthritides and the early onset of CAD requiring coronary artery bypass grafting (CABG) is not well-established.

Purpose of the Study:

  • To investigate if patients with spondyloarthritides undergo their first CABG at a younger age compared to patients without this condition.
  • To identify spondyloarthritis as a potential predictor of early-onset CAD.

Main Methods:

  • A cohort of 3852 patients undergoing their first CABG between 2001-2005 were screened preoperatively for spondyloarthritides.
  • Patient characteristics, including age and traditional cardiovascular risk factors, were compared between those with and without spondyloarthritides.
  • Multivariate analysis was used to assess the predictive value of spondyloarthritis for early CABG.

Main Results:

  • Spondyloarthritis was present in 0.78% of the CABG population.
  • Patients with spondyloarthritides were significantly younger at the time of their first CABG (mean age 60.1 years) compared to controls (mean age 66.9 years).
  • Spondyloarthritis was a stronger independent predictor of early CABG than traditional cardiovascular risk factors.

Conclusions:

  • Spondyloarthritis is a significant predictor of early coronary artery bypass grafting, independent of traditional cardiovascular risk factors.
  • The prevalence of spondyloarthritis appears higher in the CABG population, suggesting a potential link to accelerated coronary artery disease.
  • Further research is warranted to elucidate the mechanisms behind accelerated CAD in patients with spondyloarthritides.
Abstract

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