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Related Experiment Video

Updated: Jul 8, 2026

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
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Neurotrophins modulate monocyte chemotaxis without affecting macrophage function.

B Samah1, F Porcheray, G Gras

  • 1CEA, DSV, iMETI, SIV, UMR E-01 Université Paris Sud, IFR13 Institut Paris Sud Cytokines, Service d'Immuno-Virologie, Fontenay-aux Roses, France.

Clinical and Experimental Immunology
|January 15, 2008
PubMed
Summary

Neurotrophins and their receptors are expressed by macrophages, influencing their activation. Nerve growth factor (NGF) specifically enhances macrophage chemotaxis, suggesting a role in tissue repair.

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Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Neurotrophins and their receptors are crucial for nervous system development.
  • Emerging evidence highlights their roles beyond the central nervous system.
  • Macrophages play key roles in immune responses and tissue homeostasis.

Purpose of the Study:

  • To investigate neurotrophin and receptor expression in human activated macrophages.
  • To determine how neurotrophins modulate macrophage activation.
  • To explore the potential role of neurotrophins in macrophage-mediated tissue repair.

Main Methods:

  • Primary adult monocyte-derived macrophages were used.
  • Gene expression of neurotrophins and receptors was analyzed.
  • Macrophage activation and function were assessed in response to stimuli and neurotrophins.

Main Results:

  • Macrophages express neurotrophin and receptor genes differentially, with specific inductions upon stimulation.
  • Neurotrophins did not alter antigen presentation or pro-inflammatory cytokine production.
  • Nerve growth factor (NGF) increased CXCR-4 expression and chemotaxis towards CXCL-12.

Conclusions:

  • Macrophages express and differentially regulate neurotrophins and their receptors.
  • Neurotrophins modulate macrophage activation phenotype and chemotaxis.
  • NGF's effect on CXCR-4 suggests a potential role for neurotrophins in tissue-healing mechanisms.