Related Experiment Video
Updated: Jul 8, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
Published on: January 24, 2016
Interferon regulatory factor family of transcription factors and regulation of oncogenesis
Akinori Takaoka1, Tomohiko Tamura, Tadatsugu Taniguchi
1Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Abstract:
A family of transcription factors, the interferon regulatory factors (IRF), was identified originally in the context of the regulation of the type I interferon (IFN)-alpha/beta system. The IRF family has now expanded to nine members, and gene-disruption studies have revealed the critical involvement of these members in multiple facets of host defense systems, such as innate and adaptive immune responses and tumor suppression. In the present review article, we aim at summarizing our current knowledge of the roles of IRF in host defense, with special emphasis on their involvement in the regulation of oncogenesis.
More Related Videos
Related Concept Videos
Transcription Factors
Transcription Factors
General Transcription Factors
Master Transcription Regulators
Master Transcription Regulators
RNA Polymerase II Accessory Proteins

