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Updated: Jul 8, 2026

Malachite Green Assay for the Discovery of Heat-Shock Protein 90 Inhibitors
Published on: January 20, 2023
Development and application of Hsp90 inhibitors
David B Solit1, Gabriela Chiosis
1Department of Medicine and the Human Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, United States.
Abstract:
Heat shock protein 90 has emerged as an important target in several diseases. The present review will discuss our understanding of the role played by Hsp90 in regulating and maintaining the transformed phenotype in cancers and neurodegenerative diseases, as well as recent findings on its roles in fungal and viral infections. It will also update the reader on the preclinical development and clinical translation of Hsp90 inhibitors.
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