Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

Inhibitors of Viral Protein Synthesis

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrated Clinicogenomic Risk Modeling for Metachronous Second Primary Cancers.

medRxiv : the preprint server for health sciences·2026

Same author

Molecular and Clinical Determinants of Targeted Therapy Treatment in Biliary Tract Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Same author

Hypoxia shapes both therapeutic response and resistance in metastatic clear cell renal cell carcinoma.

Cancer cell·2026

Same author

Targeted Molecular Profiling of Circulating Cell-Free DNA in Patients With Gastroesophageal Adenocarcinoma.

JCO precision oncology·2026

Same author

Cancer type-specific variation in patterns of driver alterations across 50,000 tumors.

Cancer cell·2026

Same author

Efficacy and Genomic Analysis of HER2-Mutant Metastatic Triple-Negative Breast Cancer Treated with Neratinib Alone or with Trastuzumab in the SUMMIT Basket Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Malachite Green Assay for the Discovery of Heat-Shock Protein 90 Inhibitors

Malachite Green Assay for the Discovery of Heat-Shock Protein 90 Inhibitors

Published on: January 20, 2023

Development and application of Hsp90 inhibitors.

David B Solit¹, Gabriela Chiosis

¹Department of Medicine and the Human Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, United States.

Drug Discovery Today

|January 15, 2008

Summary

Heat shock protein 90 (Hsp90) is a key target for diseases like cancer and neurodegeneration. This review covers Hsp90

Area of Science:

Molecular biology
Cellular biology
Disease mechanisms

Background:

Heat shock protein 90 (Hsp90) is a crucial molecular chaperone.
Its role in protein folding and stability is vital for cellular function.
Dysregulation of Hsp90 is implicated in various pathologies.

Purpose of the Study:

To review the multifaceted roles of Hsp90 in disease.
To explore Hsp90's involvement in cancer and neurodegenerative disorders.
To summarize Hsp90's function in infectious diseases and therapeutic strategies.

Main Methods:

Literature review of existing research on Hsp90.
Analysis of Hsp90's function in different disease models.
Examination of preclinical and clinical data for Hsp90 inhibitors.

More Related Videos

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay

Published on: July 21, 2021

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

Related Experiment Videos

Last Updated: Jul 8, 2026

Malachite Green Assay for the Discovery of Heat-Shock Protein 90 Inhibitors

Malachite Green Assay for the Discovery of Heat-Shock Protein 90 Inhibitors

Published on: January 20, 2023

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay

Published on: July 21, 2021

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

Main Results:

Hsp90 is essential for maintaining the transformed phenotype in cancer cells.
Hsp90 plays a significant role in the progression of neurodegenerative diseases.
Hsp90 is implicated in the life cycle of fungal and viral pathogens.

Conclusions:

Hsp90 is a validated therapeutic target across diverse diseases.
Targeting Hsp90 offers a promising strategy for cancer, neurodegenerative, and infectious diseases.
Further development of Hsp90 inhibitors is warranted for clinical application.