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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Related Experiment Video

Updated: Jul 8, 2026

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
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Prolactin, dendritic cells, and systemic lupus erythematosus.

Luis J Jara1, Gamaliel Benitez, Gabriela Medina

  • 1Direction of Education and Research, Unidad Médica de Alta Especialización, Hospital de Especialidades, Centro Médico La Raza, IMSS, Mexico. luis_jara_quezada@hotmail.com

Autoimmunity Reviews
|January 15, 2008
PubMed
Summary

Prolactin (PRL) may drive autoimmune disease in systemic lupus erythematosus (SLE) by altering dendritic cell (DC) function. Abnormal PRL secretion and DC dysfunction are key features in SLE pathogenesis.

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Area of Science:

  • Immunology
  • Endocrinology
  • Rheumatology

Background:

  • Dendritic cells (DC) are crucial for immune tolerance and autoimmunity induction.
  • Systemic lupus erythematosus (SLE) involves a loss of self-tolerance and autoantibody production.
  • Prolactin (PRL) influences immune cell function, including DC maturation.

Purpose of the Study:

  • To investigate the role of prolactin (PRL) in the function of dendritic cells (DC) in systemic lupus erythematosus (SLE).
  • To explore the potential link between elevated serum PRL levels and disease activity in SLE patients.

Main Methods:

  • Analysis of DC function in SLE patients.
  • Correlation of serum PRL levels with disease activity and organ involvement.
  • Investigation of PRL's effect on DC phenotype and cytokine production, particularly interferon-alpha.

Main Results:

  • SLE patients exhibit altered DC function and abnormal PRL secretion.
  • High serum PRL levels are associated with active SLE and organ involvement.
  • PRL may promote a proinflammatory DC phenotype with increased interferon-alpha production.

Conclusions:

  • Dysfunctional dendritic cells and abnormal prolactin secretion are characteristic of SLE.
  • The interaction between PRL and DC may contribute significantly to the pathogenesis of SLE.
  • Targeting the PRL-DC axis could offer new therapeutic strategies for SLE.