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Updated: Jul 8, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Elevated soluble intercellular adhesion molecule-1 levels are associated with poor short-term prognosis in
Loukianos S Rallidis1, Maria G Zolindaki, Michalis Vikelis
1Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Greece. rallidis@ath.forthnet.gr
Background:
There is increasing evidence that cellular adhesion molecules (CAMs) play an important role in the pathophysiology of acute ischaemic stroke. We examined the prognostic value of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) on in-hospital mortality in patients with ischaemic stroke.
Methods:
We recruited 241 consecutive patients
Results:
Patients with acute ischaemic stroke had higher sICAM levels compared to controls [267 (220-325) versus 200 (179-225) ng/ml, p<0.001]. Sixteen (6.6%) patients died during hospitalization. sICAM-1 and sVCAM-1 levels were significantly higher in patients who died compared to those who survived [370 (324-453) versus 260 (219-313) ng/ml, p<0.001 and 790 (495-985) versus 576 (494-671) ng/ml, p=0.01, respectively] but only sICAM-1 levels were independently associated with early death, after adjusting for various confounding factors. For 10 ng/ml increase in sICAM-1 levels there was a 9% higher risk of dying. Cut-off point analysis revealed that sICAM-1 levels >322 ng/ml were the optimal points that discriminated those who died from the rest of the patients.
Conclusions:
High sICAM-1 levels on admission are associated with early death in ischaemic middle-aged stroke patients suggesting a pathogenetic role of inflammation in the evolution of ischaemic stroke.
