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Related Experiment Video

Updated: Jul 8, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Association study between obsessive-compulsive disorder and serotonergic candidate genes.

Pilar A Saiz¹, Maria P Garcia-Portilla, Celso Arango

¹Department of Psychiatry, School of Medicine, University of Oviedo, Julian Claveria 6-3, 33006 Oviedo, Spain. frank@uniovi.es

Progress in Neuro-Psychopharmacology & Biological Psychiatry

|January 15, 2008

Summary

This study found an association between the STin2 VNTR polymorphism in the SLC6A4 gene and obsessive-compulsive disorder (OCD). This genetic finding may contribute to understanding OCD

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Area of Science:

Genetics
Psychiatry
Neuroscience

Background:

Research on serotonergic genes and obsessive-compulsive disorder (OCD) has produced inconsistent findings.
Investigating specific genetic variations is crucial for understanding OCD's etiology.

Purpose of the Study:

To examine the association between four serotonergic gene polymorphisms and OCD.
Specifically investigated STin2 VNTR and 5-HTTLPR (SLC6A4 gene), and A-1438G and T102C (HTR2A gene).

Main Methods:

Genotyping of 99 OCD patients, 456 non-OCD psychiatric patients, and 420 healthy controls.
Participants were from a homogeneous Spanish Caucasian population.
Standard genotyping methods were employed.

Main Results:

The STin2 VNTR polymorphism showed a significant association with OCD.
OCD patients had a higher frequency of STin2.12 carriers compared to healthy and non-OCD psychiatric controls.
No significant associations were found for A-1438G and 5-HTTLPR polymorphisms.

Conclusions:

The STin2 VNTR polymorphism in the SLC6A4 gene is associated with obsessive-compulsive disorder.
These findings support a role for specific serotonergic genetic variations in OCD.
Further research is warranted to elucidate the precise mechanisms involved.