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Infantile pyoderma gangrenosum
Maeve A McAleer1, Frank C Powell, Deirdre Devaney
1Regional Centre of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland. maeve_mc_aleer@hotmail.com
Journal of the American Academy of Dermatology
|January 23, 2008
Summary
Pyoderma gangrenosum (PG) is rare in infants. This case highlights cyclosporine as a vital treatment for aggressive infantile PG unresponsive to steroids.
Area of Science:
- Dermatology
- Pediatrics
Background:
- Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis.
- Infantile PG is exceptionally uncommon, with limited documented cases.
Observation:
- An 8-month-old infant presented with aggressive PG.
- The infant's condition was refractory to systemic corticosteroid therapy.
Findings:
- Successful healing was achieved with adjuvant cyclosporine treatment.
- Review of 12 reported infantile PG cases shows variable steroid responsiveness.
Implications:
- Cyclosporine offers a potential therapeutic option for severe infantile PG.
- Further research into optimal infantile PG management is warranted.
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