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Related Experiment Videos

Infantile pyoderma gangrenosum.

Maeve A McAleer1, Frank C Powell, Deirdre Devaney

  • 1Regional Centre of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland. maeve_mc_aleer@hotmail.com

Journal of the American Academy of Dermatology
|January 23, 2008
PubMed
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Pyoderma gangrenosum (PG) is rare in infants. This case highlights cyclosporine as a vital treatment for aggressive infantile PG unresponsive to steroids.

Area of Science:

  • Dermatology
  • Pediatrics

Background:

  • Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis.
  • Infantile PG is exceptionally uncommon, with limited documented cases.

Observation:

  • An 8-month-old infant presented with aggressive PG.
  • The infant's condition was refractory to systemic corticosteroid therapy.

Findings:

  • Successful healing was achieved with adjuvant cyclosporine treatment.
  • Review of 12 reported infantile PG cases shows variable steroid responsiveness.

Implications:

  • Cyclosporine offers a potential therapeutic option for severe infantile PG.
  • Further research into optimal infantile PG management is warranted.