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Updated: Jul 8, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
Control of transcription in Schistosoma mansoni: chromatin remodeling and other regulatory elements
Marcelo Rosado Fantappíé1, Francisco M Bastos de Oliveira, Renata de Moraes Maciel dos Santos
1Instituto de Bioquímica Médica, Programa de Biologia Molecular e Biotecnologia, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Cidade Universitária, CEP 21941-590, Rio de Janeiro, Brazil.
Abstract:
The platyhelminth parasite Schistosoma mansoni, the causative agent of schistosomiasis, is a dioecious parasite with a complex life cycle that includes two different hosts and two free-living stages. Yet very little is known about the biochemical details connected to these different transitions. In the present work, results will be presented showing the most recent results in S. mansoni regarding the characterization of transcription factors and coactivators that act directly on the transcriptional machinery and those that are involved with chromatin remodeling. It is hoped that the information gathered here may contribute towards the understanding of crucial events in the parasite life cycle. Likewise, the development of new drugs that could interfere with oogenesis and sexual maturation may eventually profit from the information contained herein.
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