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Updated: Jul 8, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Maternal microchimerism in human fetal tissues.

Anna Maria Jonsson¹, Mehmet Uzunel, Cecilia Götherström

¹Department of Obstetrics and Gynecology, the Center for Fetal Medicine, Karolinska University Hospital, Huddinge, Sweden. anna.jonsson@karolinska.se

American Journal of Obstetrics and Gynecology

|January 15, 2008

Summary

Maternal microchimerism, the presence of maternal cells in fetal tissues, is common in second-trimester human fetuses. These maternal cells, including immune cells and stem cells, are widely distributed throughout fetal tissues.

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Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

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Last Updated: Jul 8, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Area of Science:

Reproductive biology
Immunology
Developmental biology

Background:

Maternal microchimerism involves the bidirectional transfer of cells between mother and fetus.
Understanding the extent and distribution of maternal cells in fetal tissues is crucial for pregnancy research.

Purpose of the Study:

To investigate the presence and distribution of maternal cells within human fetal tissues during the second trimester of gestation.

Main Methods:

Analysis of fetal tissues from 11 second-trimester fetuses.
Utilized cell sorting and polymerase chain reaction (PCR) to detect maternal CD3+, CD19+, CD34+, and CD45+ cells.
Examined tissues from fetuses with normal karyotypes and those with trisomy 21 and/or malformations.

Main Results:

Maternal microchimerism was detected in 4 out of 5 fetuses with normal karyotypes and autopsy findings.
Cells of maternal origin were identified in 3 out of 6 fetuses diagnosed with trisomy 21 and/or malformations.
Maternal cells were found in various fetal tissues and the placenta.

Conclusions:

Maternal microchimerism is a prevalent occurrence in human fetuses during the second trimester.
Maternal lymphoid, myeloid, and hematopoietic progenitor cells are broadly distributed in second-trimester fetal tissues.