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Nociceptin/orphanin FQ reverses mecamylamine-induced learning and memory impairment as well as decrease in
Masayuki Hiramatsu1, Masaya Miwa, Kazuki Hashimoto
1Laboratory of Neuropsychopharmacology, Graduate School of Environmental and Human Sciences, Meijo University, 150 Yagotoyama, Tenpaku-ku, Nagoya 468-8503, Japan. mhiramt@ccmfs.meijo-u.ac.jp
Brain Research
|January 15, 2008
Summary
Nociceptin, a neuropeptide, enhances learning and memory by counteracting mecamylamine-induced deficits. These beneficial effects on cognitive function and acetylcholine release appear independent of NOP receptors.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Nociceptin/orphanin FQ is an endogenous neuropeptide involved in learning and memory.
- Previous studies showed nociceptin improved scopolamine-induced memory impairment in mice.
Purpose of the Study:
- To investigate the effects of nociceptin on mecamylamine-induced learning and memory impairment in rats.
- To determine if nociceptin affects acetylcholine release in the hippocampus.
Main Methods:
- Rats received mecamylamine to induce learning/memory impairment and reduced hippocampal acetylcholine release.
- Nociceptin was administered intracerebroventricularly.
- Acetylcholine release was measured using in vivo microdialysis.
- The role of NOP receptors was assessed using a specific antagonist.
Main Results:
- Mecamylamine impaired learning and memory and decreased hippocampal acetylcholine release.
- Nociceptin administration reversed these mecamylamine-induced impairments.
- Nociceptin also blocked the decrease in acetylcholine release.
- These effects were not blocked by a NOP receptor antagonist.
Conclusions:
- Nociceptin ameliorates mecamylamine-induced deficits in learning, memory, and acetylcholine release.
- The protective effects of nociceptin may not involve NOP receptors.
