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Correlation between ventricular enlargement and white matter changes.

Yuichiro Inatomi1, Toshiro Yonehara, Yoichiro Hashimoto

  • 1Department of Neurology, Stroke Center, Saiseikai Kumamoto Hospital, Chikami 5-3-1, Kumamoto 861-4193, Japan. y.inatomix@silk.ocn.ne.jp

Journal of the Neurological Sciences
|January 15, 2008
PubMed
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In healthy adults, larger ventricles correlate with white matter changes like periventricular hyperintensity. Age and hypertension significantly impact these white matter changes, but their link to normal pressure hydrocephalus remains unclear.

Area of Science:

  • Neurology
  • Radiology
  • Gerontology

Background:

  • White matter changes, including periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH), are common findings on MRI.
  • The clinical significance of these changes in normal pressure hydrocephalus (NPH) is not fully understood.
  • Investigating these changes in a healthy population can provide a baseline for comparison.

Purpose of the Study:

  • To investigate the correlation between ventricular size and white matter changes in neurologically normal adults.
  • To identify clinical factors influencing ventricular enlargement and white matter changes.

Main Methods:

  • MRI scans were performed on 683 neurologically normal adults (mean age 59).
  • Evans' index was used to measure ventricular size.

Related Experiment Videos

  • The severity of PVH and DWMH was graded.
  • Correlation and multiple linear regression analyses were employed.

    • Main Results:

    • A weak but significant correlation was found between Evans' index and the grading of both PVH (rho=0.24) and DWMH (rho=0.24).
    • Age, diastolic blood pressure, Evans' index, and a history of hypertension significantly impacted PVH grade.
    • Age and a history of hypertension were significantly related to DWMH grade.
    • An independent correlation between ventricular enlargement and PVH was observed in normal adults.

    Conclusions:

    • Ventricular enlargement shows an independent correlation with periventricular hyperintensity in healthy adults.
    • Factors such as age, blood pressure, and hypertension history influence white matter changes.
    • The findings in a normal population may indicate preclinical disease, but their relevance to normal pressure hydrocephalus requires further investigation.