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Supercritical Fluid Chromatography

Supercritical Fluid Chromatography

Supercritical fluid chromatography (SFC) provides a beneficial substitute for gas chromatography (GC) and liquid chromatography (LC) for certain samples because it merges the top attributes of both techniques. SFC allows the separation and analysis of compounds that GC or LC does not easily manage. These compounds are traditionally nonvolatile or thermally unstable, making GC unsuitable and lacking functional groups required for HPLC analysis.
SFC utilizes a supercritical fluid mobile phase,...

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Related Experiment Video

Updated: Jul 8, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Nanoparticles synthesis using supercritical fluid technology - towards biomedical applications.

K Byrappa¹, S Ohara, T Adschiri

¹University of Mysore, P.B. No.21, Manasagangotri, Mysore 570 006, India.

Advanced Drug Delivery Reviews

|January 15, 2008

Summary

Supercritical fluid (SCF) technology enables precise control over nanomaterial size and morphology. This review highlights SCF

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Last Updated: Jul 8, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

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Published on: August 28, 2015

Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Supercritical fluid (SCF) technology is a key materials processing tool.
Supercritical CO2 and H2O are widely used for nanomaterial synthesis.
Nanomaterial properties are highly dependent on size and morphology.

Purpose of the Study:

To review nanomaterial preparation using SCF technology for biomedical applications.
To detail SCF processing principles, merits, and perspectives for inorganic and hybrid nanomaterials.
To discuss experimental data on SCF-synthesized nanomaterials for biomedical uses.

Main Methods:

Systematic review of nanomaterial preparation using SCF technology.
Detailed explanation of basic SCF processing principles.
Discussion of experimental results for selected nanomaterials.

Main Results:

SCF technology offers significant control over nanoparticle size, morphology, and surface properties.
Various nanomaterials like phosphors, magnetic materials, and carbon nanotubes can be synthesized using SCF.
SCF synthesis facilitates in situ surface modification and dispersibility.

Conclusions:

SCF technology is crucial for fabricating advanced nanomaterials for biomedical applications.
Precise control over nanomaterial characteristics via SCF enhances their potential in diagnostics and therapeutics.
Further research into SCF methods will advance targeted drug delivery, bio-imaging, and cancer therapy.