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[A non-exocrine function of the submaxillary gland]
1Département de Sciences Biologiques, Faculté de Chirurgie Dentaire, Université Montpellier I.
Annales D'Endocrinologie
|January 1, 1991
Summary
Submandibular salivary glands (SSG) secrete growth factors like EGF and NGF, acting as endocrine signals. Deficiencies in these factors are linked to oral diseases and impact reproductive and central nervous system functions.
Area of Science:
- Endocrinology
- Cellular Biology
- Neuroscience
Context:
- Submandibular salivary glands (SSG) synthesize and secrete signaling molecules.
- These molecules, including growth factors like EGF and NGF, may have endocrine functions.
- The concept of 'banalization' and multifactoriality of cellular communication is considered.
Purpose:
- To review literature linking SSG-synthesized substances to endocrine roles.
- To explore the correlation between SSG growth factor deficits and oral pathologies.
- To investigate the impact of SSG removal on reproductive function and the central nervous system.
Summary:
- SSG secrete growth factors (EGF, NGF) with potential endocrine roles, impacting oral health and systemic functions.
- Deficits in these factors correlate with oral pathologies (aphthous lesions, gingivitis) and autoimmune salivary diseases.
- SSG removal affects reproductive markers (LH, Leydig cells) and CNS structures (hypothalamus, pineal gland).
Impact:
- Suggests SSG growth factors play a role in reproductive health and CNS regulation.
- Highlights potential links between SSG function, stress response, and immune system modulation.
- Proposes NGF as a stress signal connecting peripheral immunity, CNS, and the hypothalamic-pituitary-adrenal axis.