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Updated: Jul 8, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

Elevated serum creatinine levels associated with fenofibrate therapy.

Charles R McQuade¹, Jennifer Griego, Joe Anderson

¹University of New Mexico College of Pharmacy, Albuquerque, NM 87131, USA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists

|January 15, 2008

Summary

Fenofibrate therapy may cause kidney damage in patients with chronic kidney disease (CKD). Discontinuation of fenofibrate led to improved kidney function in a case study of a patient with hypertriglyceridemia.

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Last Updated: Jul 8, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

Area of Science:

Nephrology
Pharmacology
Internal Medicine

Background:

Fenofibrate is a medication used to treat hypertriglyceridemia.
Chronic kidney disease (CKD) affects kidney function and requires careful medication management.
Patients with CKD are at increased risk for adverse drug events.

Observation:

A 60-year-old male with stage 4 CKD was treated with fenofibrate for hypertriglyceridemia.
The patient experienced a significant increase in serum creatinine (SCr) and blood urea nitrogen (BUN) levels, with a decrease in estimated glomerular filtration rate (eGFR) after initiating fenofibrate.
Despite dose adjustments, renal function continued to decline, necessitating preparation for hemodialysis.

Findings:

Discontinuation of fenofibrate resulted in a notable drop in SCr levels and a return of eGFR to baseline within six weeks.
The Naranjo probability scale suggested a possible association between fenofibrate use and the observed renal dysfunction.
The patient's renal function remained stable for 12 months after discontinuing fenofibrate.

Implications:

This case highlights the potential nephrotoxic effects of fenofibrate in patients with pre-existing CKD.
Clinicians should monitor renal function closely in patients with CKD receiving fenofibrate.
Further research may be warranted to elucidate the mechanisms of fenofibrate-induced renal impairment and identify at-risk populations.