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Two cases of bizarre rib anomalies associated with intestinal malformation
1Department of Pediatric Surgery, Tohoku University School of Medicine, Sendai, Japan.
Insights
This study presents two rare cases of severe skeletal anomalies alongside intestinal malformations. Both patients underwent successful intestinal surgeries despite significant rib and vertebral defects.
Area of Science:
- Pediatric Surgery
- Medical Genetics
- Developmental Biology
Background:
- Intestinal malformations like ileal atresia, Hirschsprung's disease, and anorectal malformation can present with complex congenital anomalies.
- Skeletal abnormalities, particularly involving ribs and vertebrae, are occasionally associated with gastrointestinal tract developmental defects.
Observation:
- Two pediatric cases exhibited unusual and severe skeletal anomalies concurrently with intestinal malformations.
- One patient presented with ileal atresia and Hirschsprung's disease, while the other had an anorectal malformation.
- Both patients displayed significant abnormalities in the number and morphology of ribs and vertebrae.
Findings:
- The observed skeletal malformations were notably severe, including costal anomalies.
- Despite the severity of skeletal defects, both patients tolerated surgical correction of their intestinal conditions without complications.
- This suggests that severe skeletal anomalies may not necessarily contraindicate or complicate intestinal surgery in these specific cases.
Implications:
- These cases highlight a potential, albeit rare, association between severe skeletal and intestinal malformations.
- Further research may elucidate the underlying genetic or developmental pathways involved in these concurrent anomalies.
- The findings support the feasibility of surgical intervention for intestinal malformations even in the presence of significant, co-occurring skeletal abnormalities.
Abstract:
Two cases of bizarre skeletal anomalies associated with intestinal malformation are presented. One patient had ileal atresia and Hirschsprung's disease, and the other anorectal malformation. Abnormalities in the number and morphology of ribs and vertebrae were present. Esophageal atresia often is associated with skeletal abnormalities, including supernumerary ribs, but these usually are not severe. Despite their severe costal malformations, neither patient had any complication after surgery to correct their intestinal malformation.