Related Experiment Video
Updated: Jul 8, 2026
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
Published on: August 12, 2019
Correlative studies of structural and functional imaging in primary progressive aphasia
P K Panegyres1, M McCarthy, A Campbell
1Neurosciences Unit, Health Department of Western Australia, Mt Claremont, Western Australia, Australia. macfarlane4@optusnet.co.au
Rationale:
To compare and contrast structural and functional imaging in primary progressive aphasia (PPA).
Methods:
A cohort of 8 patients diagnosed with PPA presenting with nonfluency were prospectively evaluated. All patients had structural imaging in the form of MRI and in 1 patient CAT scanning on account of a cardiac pacemaker. All patients had single-photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging.
Results:
SPECT and PET imaging had 100% correlation. Anatomical imaging was abnormal in only 6 of the 8 patients. Wernicke's area showed greater peak Z score reduction and extent of area affected than Broca's area (McNemar paired test: P = .008 for Z score reduction; P = .0003 for extent). PET scanning revealed significant involvement of the anterior cingulum.
Conclusion:
Functional imaging in PPA: (a) identified more patients correctly than anatomic imaging highlighting the importance of SPECT and PET in the diagnosis; and (b) demonstrated the heterogeneous involvement of disordered linguistic networks in PPA suggesting its syndromic nature.
More Related Videos
Related Concept Videos
01:14Brain Imaging
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
01:27Imaging Studies IV: Magnetic Resonance Imaging
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET