A case of ADHD and a major Y chromosome abnormality
Aisling Mulligan1, Michael Gill, Michael Fitzgerald
1Trinity Centre for Health Sciences, St. James Hospital, Dublin, Ireland. mulliga@tcd.ie
Background:
ADHD is a common, heritable disorder of childhood. Sex chromosome abnormalities are relatively rare conditions that are sometimes associated with behavioral disorders.
Method:
The authors present a male child with ADHD and a major de-novo Y chromosome abnormality consisting of deletion of the long arm and duplication of the short arm. It is possible that the Y chromosomal abnormality is causing the ADHD syndrome in this boy.
Conclusion:
Considering this case and considering that (a) ADHD is more common in boys than in girls, (b) the transmission of some genes associated with ADHD may occur preferentially from fathers rather than from mothers, and (c) ADHD is more common in children with XYY syndrome and Turner's syndrome than in other children, the authors propose that the sex chromosomes may contain risk genes for ADHD.
More Related Videos
08:22A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene
Published on: September 16, 2019
08:22A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
Published on: December 1, 2017
Related Concept Videos
Sex-linked Disorders
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
X and Y Chromosomes
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The Y Chromosome Determines Maleness
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
Pedigree Analysis
Karyotyping
