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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Preclinical Development: Overview01:28

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
The Citric Acid Cycle02:36

The Citric Acid Cycle

The citric acid cycle, also known as the Krebs cycle or TCA cycle, consists of several energy-generating reactions that yield one ATP molecule, three NADH molecules, one FADH2 molecule, and two CO2 molecules.

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Enhanced Sample Multiplexing of Tissues Using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)
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The CITRA pilot studies program: mentoring translational research.

Elaine Wethington1, Risa Breckman, Rhoda Meador

  • 1Department of Human Development, Cornell University, MVR Hall, Ithaca, NY 14853, USA. ew20@cornell.edu

The Gerontologist
|January 15, 2008
PubMed
Summary

This study created a pilot program to link university researchers with NYC agencies serving older adults. This fosters community-based research for evidence-based practices benefiting seniors.

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Area of Science:

  • Translational Research
  • Community-Based Participatory Research (CBPR)
  • Gerontology and Aging Services Research

Background:

  • Bridging the gap between academic research and community practice is crucial for improving services for older adults.
  • Effective translation of scientific findings into evidence-based practices requires strong partnerships between researchers and service agencies.
  • Community-dwelling older adults benefit most when research directly addresses their needs and is applicable to frontline services.

Purpose of the Study:

  • To develop an innovative pilot studies program fostering collaborations between university researchers and New York City agencies serving older adults.
  • To facilitate the translation of scientific research into evidence-based practices for community-dwelling older adults.
  • To establish a model for effective researcher-agency partnerships in aging research.

Main Methods:

  • Adapted the traditional academic pilot studies model incorporating key features of community-based participatory research (CBPR).
  • Developed a multistep program in partnership with 265 senior centers and service agencies.
  • Recruited and educated investigators and agencies on CBPR principles and funded research partnerships.

Main Results:

  • Successfully built a program to recruit, educate, and fund research partnerships between university researchers and community agencies.
  • Ensured research partnerships met essential criteria for translation: scientific rigor, community needs sensitivity, and frontline practice applicability.
  • Established an educational and monitoring infrastructure to support pilot research projects.

Conclusions:

  • Pilot studies programs for CBPR necessitate a robust infrastructure to support individual efforts with centralized resources for implementation and dissemination.
  • The financial and time commitment for maintaining such programs can be a significant barrier to their establishment.
  • Centralized support is vital for ensuring the proper execution and widespread adoption of research findings in aging services.