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Updated: Jul 8, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Letter: Lanthanum-calcium-manganate (La0.67Ca0.33MnO3) nanoparticle assisted affinity probes for MALDI MS analysis of
Abstract:
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) has been used extensively for the analysis of -intact proteins and for proteomics. Proteins or proteomics analyses with low molecular mass range have some limitations because of background interference from the salt or surfactant ions. Lanthanum-calcium- manganate La(0.67)Ca(0.33)MnO(3) nanoparticles (LCMONPs) have been used as the matrix-assisting material after surface modification to reduce the salt or surfactant interference. The detectable mass range was tested in the range of 800-16,000 Da. The surface-modified LCMONPs have affinity with protein molecules through ionic or electrostatic interaction at pH 4.0. The nanoparticles mixed with proteins give a spectrum with a large signal-to-noise ratio for the analytes, and effectively eliminate the noise from interfering salt or surfactant ions. The results indicate that surface-modified La(0.67)Ca(0.33)MnO(3) nanoparticles can be used with MALDI matrix for proteins to eliminate the excessive noise of selective surfactants or salt ions from the MALDI spectrum.
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