Does repeated Ramadan fasting adversely affect kidney function in renal transplant patients?

Area of Science:

• Nephrology
• Transplantation Medicine
• Religious Studies

Background:

• Fasting during Ramadan is a religious practice observed by millions worldwide.
• The impact of intermittent fasting on renal transplant recipients remains a significant clinical question.
• Understanding potential risks to kidney function is crucial for patient management.

Purpose of the Study:

• To evaluate the long-term effects of Ramadan fasting on renal function in kidney transplant recipients.
• To compare changes in estimated glomerular filtration rate (eGFR), mean arterial pressure (MAP), and proteinuria between fasters and non-fasters.
• To identify factors influencing eGFR changes in fasting transplant patients.

Main Methods:

• Prospective cohort study involving 35 Ramadan fasters and 33 non-fasters.
• Baseline and post-third Ramadan measurements of eGFR, MAP, and urinary protein excretion.
• Statistical analysis adjusted for age, diabetes mellitus, baseline eGFR, proteinuria, and time post-transplantation.

Main Results:

• No significant change in eGFR was observed among fasters after three Ramadans (56.4 vs. 55.4 mL/min, P=0.8).
• Adjusted analyses confirmed no impact of fasting on eGFR, considering age, diabetes, proteinuria, or time post-transplantation.
• No significant differences in changes of eGFR, MAP, or proteinuria between fasters and non-fasters.

Conclusions:

• Fasting during Ramadan for three consecutive years does not adversely affect renal function in stable renal transplant recipients.
• Ramadan fasting appears safe for kidney transplant patients, with no significant impact on key renal parameters.
• Further research may explore specific subgroups or different fasting durations.