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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
Bioequivalence studies: Biowaivers01:13

Bioequivalence studies: Biowaivers

In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...

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Related Experiment Video

Updated: Jul 8, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Gateways to clinical trials.

M Bayés1, X Rabasseda, J R Prous

  • 1Prous Science, Barcelona, Spain. mbayes@prous.com

Methods and Findings in Experimental and Clinical Pharmacology
|January 15, 2008
PubMed
Summary
This summary is machine-generated.

This study provides a comprehensive list of novel pharmaceutical compounds and drug candidates currently in development. It serves as a valuable resource for researchers tracking emerging therapeutics across various medical fields.

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In Silico Clinical Trials for Cardiovascular Disease
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In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

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Last Updated: Jul 8, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Area of Science:

  • Pharmaceutical Sciences
  • Drug Discovery and Development
  • Medicinal Chemistry

Context:

  • The landscape of pharmaceutical research is rapidly evolving with continuous innovation in drug discovery.
  • Identifying and categorizing new chemical entities and biological drugs is crucial for scientific advancement.
  • A systematic overview of emerging drug candidates aids in understanding current research trends and potential therapeutic breakthroughs.

Purpose:

  • To compile and present a diverse list of pharmaceutical compounds and drug candidates.
  • To highlight novel therapeutics under investigation across multiple disease areas.
  • To provide a reference for researchers, clinicians, and industry professionals tracking drug development.

Summary:

  • The abstract lists a wide array of pharmaceutical compounds, including small molecules, biologics, and drug conjugates.
  • It encompasses agents targeting various therapeutic areas such as oncology, infectious diseases, cardiovascular conditions, and autoimmune disorders.
  • The list includes both established drug classes and novel agents, reflecting the breadth of current pharmaceutical research.

Impact:

  • Facilitates the identification of potential drug targets and therapeutic strategies.
  • Supports the strategic planning and resource allocation in pharmaceutical research and development.
  • Enhances knowledge dissemination within the scientific community regarding the latest advancements in drug discovery.