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Related Concept Videos

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Related Experiment Video

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Analysis of Spliceosomal snRNA Localization in Human Hela Cells Using Microinjection
07:35

Analysis of Spliceosomal snRNA Localization in Human Hela Cells Using Microinjection

Published on: August 6, 2019

Invertebrate 7SK snRNAs.

Andreas R Gruber1, Dorota Koper-Emde, Manja Marz

  • 1Institute for Theoretical Chemistry, University of Vienna, Währingerstrasse 17, A-1090 Wien, Austria. agruber@tbi.univie.ac.at

Journal of Molecular Evolution
|January 15, 2008
PubMed
Summary

Researchers discovered 7SK RNA, a crucial noncoding RNA, in diverse invertebrates like mollusks and annelids. This finding expands our understanding of its evolutionary conservation and functional importance in gene regulation.

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Area of Science:

  • Molecular Biology
  • Evolutionary Biology
  • Genomics

Background:

  • 7SK RNA is a highly abundant noncoding RNA in mammalian cells, essential for transcriptional regulation.
  • Its sequence is conserved in vertebrates, but homologues were previously undiscovered in invertebrates.

Purpose of the Study:

  • To investigate the evolutionary presence of 7SK RNA beyond vertebrates.
  • To identify 7SK RNA homologues in diverse invertebrate phyla using experimental and computational methods.

Main Methods:

  • Bioinformatic analysis of available genomes from various invertebrate clades.
  • Experimental screening for 7SK RNA sequences in selected invertebrate species.
  • Comparative sequence analysis to identify conserved structural motifs.

Main Results:

  • 7SK RNAs were successfully identified in major deuterostome clades and in two protostome phyla: mollusks and annelids.
  • No 7SK RNA candidates were found in ecdysozoan genomes despite extensive searching.
  • Sequence data confirmed conserved 3' and 5' stem-loop motifs and revealed a third conserved domain.

Conclusions:

  • 7SK RNA is more widely conserved across the animal kingdom than previously thought, extending to certain protostomes.
  • The discovery highlights the ancient evolutionary origins and conserved functional importance of 7SK RNA.
  • Further research into the functional roles of 7SK RNA in these newly identified species is warranted.