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Updated: Jul 8, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

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[Gene regulation by steroid receptors]

Ichiro Takada1, Shigeaki Kato

  • 1Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, The University of Tokyo.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 15, 2008
PubMed

Insights

Steroid hormone receptors control cell functions. While their basic mechanisms are understood, how they are regulated by tissues and external signals remains an active research area.

Area of Science:

  • Molecular biology
  • Endocrinology
  • Genetics

Context:

  • Steroid hormone receptors are crucial transcriptional factors regulating vital cellular processes.
  • Recent advances include genome-wide identification of target genes and proteomic analysis of cofactors.

Purpose:

  • To elucidate the molecular mechanisms of steroid hormone receptor function.
  • To investigate the tissue-specific and extracellular signal-dependent regulation of these receptors.

Summary:

  • Steroid hormone receptors, ligand-dependent transcriptional factors, regulate cell differentiation, proliferation, and homeostasis.
  • Genome-wide and proteomic analyses have revealed many target genes and associated cofactors, clarifying ligand-dependent transactivation.
  • The precise tissue-specific and extracellular signal-dependent regulation of these receptors requires further investigation.

Impact:

  • Enhances understanding of gene regulation by steroid hormones.
  • Provides a foundation for future research into complex regulatory networks.
  • Contributes to the fields of molecular endocrinology and transcriptional regulation.

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