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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

Calcium and cardiomyopathies

E G Kranias1, D M Bers

  • 1Department of Pharmacology & Cell Biophysics, College of Medicine,University of Cincinnati, OH 45267-0575, USA. Litsa.kranias@uc.edu

Sub-Cellular Biochemistry
|January 16, 2008
PubMed

Insights

Sarcoplasmic reticulum (SR) proteins regulate cardiac calcium (Ca) cycling, essential for heart function. Genetic variants in these proteins are linked to heart failure and arrhythmias.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biochemistry

Background:

  • Cardiac excitation-contraction (E-C) coupling relies on sarcoplasmic reticulum (SR) calcium (Ca) cycling.
  • Dysfunctional Ca cycling in the SR network characterizes cardiac hypertrophy and heart failure.
  • Key SR Ca-handling proteins include SERCA, phospholamban (PLN), calsequestrin, and the ryanodine receptor (RyR).

Purpose of the Study:

  • To review the critical role of SR Ca-cycling proteins in cardiac health and disease.
  • To highlight recent findings on genetic modifiers of SR Ca-cycling proteins.

Main Methods:

  • Review of existing literature on SR Ca-cycling proteins.
  • Focus on genetic variants and their impact on cardiomyopathies.
  • Analysis of protein function in cardiac relaxation, Ca-load, and Ca-release.

Main Results:

  • Altered levels or activity of SERCA, PLN, calsequestrin, and RyR are observed in cardiomyopathies.
  • These alterations correlate with impaired cardiac function and remodeling.
  • Genetic variations in SR Ca-cycling proteins can predispose individuals to heart failure and arrhythmias.

Conclusions:

  • SR Ca-cycling proteins are pivotal in maintaining cardiac function.
  • Dysregulation and genetic variants of these proteins are implicated in heart disease pathogenesis.
  • Understanding these proteins and their genetic modifiers is crucial for diagnosing and treating cardiomyopathies.

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