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Updated: Jul 8, 2026
07:01
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Spotlight on topiramate in epilepsy
Katherine A Lyseng-Williamson1, Lily P H Yang
1Wolters Kluwer Health Adis, Auckland, New Zealand. demail@adis.co.nz
CNS Drugs
|January 16, 2008
Summary
Topiramate (Topamax) is an effective antiepileptic drug for various seizure types in adults and children. Slow dosage titration can minimize adverse events, making it a valuable treatment option.
Area of Science:
- Neurology
- Pharmacology
Background:
- Topiramate is a broad-spectrum antiepileptic drug (AED) with proven efficacy.
- It is used for generalized tonic-clonic seizures, partial seizures, and Lennox-Gastaut syndrome in adults and children.
Purpose of the Study:
- To review the efficacy and tolerability of topiramate in epilepsy treatment.
- To highlight its advantages as monotherapy or adjunctive therapy.
Main Methods:
- Review of clinical data on topiramate's use in epilepsy.
- Analysis of adverse events, drug interactions, and effects on oral contraceptives.
Main Results:
- Slow titration can reduce the incidence and severity of adverse events, including CNS-related events.
- Topiramate exhibits few clinically significant drug interactions and is effective with other AEDs.
- It is not associated with drug-induced weight gain and does not interfere with oral contraceptives at lower doses.
Conclusions:
- Topiramate is a valuable therapeutic option for epilepsy in both adult and pediatric populations.
- Its favorable side-effect profile and drug interaction characteristics enhance its utility.
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