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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
Published on: November 10, 2023
[Pulmonary infections after lung transplantation]
Krisztina Czebe1, Balázs Antus, Marina Varga
1Országos Korányi Tbc- és Pulmonológiai Intézet III. Tüdobelosztály, Budapest. czebekrisztina@freemail.hu
Orvosi Hetilap
|January 16, 2008
Summary
Lung transplant recipients face high infection risks, with bacterial pneumonia and opportunistic infections like Aspergillus, Candida, and cytomegalovirus (CMV) being common causes of morbidity and mortality. Prophylactic antibiotics and antifungals, along with vigilant screening, are crucial for managing these post-transplant pulmonary infections.
Area of Science:
- Pulmonary Medicine
- Transplant Surgery
- Infectious Diseases
Context:
- Lung transplantation is a vital treatment for end-stage lung diseases.
- Over 20,000 lung transplants performed globally in two decades.
- Improved immunosuppression reduced rejection mortality to 2%.
Purpose:
- To review common pulmonary infections in lung transplant recipients.
- To discuss clinical manifestations, diagnosis, and treatment strategies.
- To highlight the shift in mortality causes from rejection to infection.
Summary:
- Infections are now the primary cause of death post-lung transplant, accounting for 21.2% within 30 days and 40% within one year.
- Bacterial pneumonia (esp. Pseudomonas) affects 35-70% in the first month; prophylactic antibiotics are essential.
- Invasive fungal and cytomegalovirus (CMV) infections increase after prophylactic treatments cease, and bronchiolitis obliterans syndrome (BOS) predisposes to late-stage infections.
Impact:
- Emphasizes the critical role of infection management in lung transplant outcomes.
- Highlights the need for tailored prophylactic and treatment regimens.
- Underscores the importance of ongoing screening and early intervention for pulmonary infections.
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