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Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
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Published on: May 10, 2018

Multiple endocrinopathies associated with lithium therapy.

Rinkoo Dalan1, Melvin Khee Shing Leow, Michelle Jong

  • 1Department of Endocrinology, Tan Tock Seng Hospital, Tan Tock Seng, Singapore.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|January 16, 2008
PubMed
Summary

Lithium therapy can cause serious endocrine issues, including primary hyperparathyroidism, hyperthyroidism, and nephrogenic diabetes insipidus. Clinicians must monitor patients for these lithium side effects.

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Nephrology

Background:

  • Lithium is a mood stabilizer used for bipolar disorder.
  • Long-term lithium use can lead to various endocrine complications.
  • Awareness of these side effects is crucial for patient management.

Observation:

  • A 65-year-old woman on lithium developed primary hyperparathyroidism and hyperthyroidism.
  • Post-lithium discontinuation, hyperthyroidism worsened, requiring carbimazole treatment.
  • She subsequently developed nephrogenic diabetes insipidus, treated with amiloride.

Findings:

  • A parathyroid adenoma was found during parathyroidectomy.
  • Causality assessment suggested lithium was likely related to all three conditions.
  • This case highlights the spectrum of lithium-induced endocrinopathies.

Implications:

  • Lithium-associated endocrinopathies require vigilant monitoring and management.
  • Clinicians must be aware of potential lithium side effects.
  • Early detection and intervention are key to managing these complications.