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Microdialysis study of imipenem distribution in the peritoneal fluid of rats with experimental acute pancreatitis
Sandrine Lefeuvre1, Sandrine Marchand, Claudine Pariat
1INSERM, ERI-23, Pôle Biologie Santé, 40 Avenue du Recteur, 86000 Poitiers, France.
Imipenem distribution was characterized by microdialysis in the peritoneal fluid of rats with experimental pancreatitis. The ratios of peritoneal fluid to blood area under unbound concentration-versus-time curves were close to unity, suggesting that imipenem was not degraded in peritoneal fluid.
Imipenem distribution was characterized by microdialysis in the peritoneal fluid of rats with experimental pancreatitis. The ratios of peritoneal fluid to blood area under unbound concentration-versus-time curves were close to unity, suggesting that imipenem was not degraded in peritoneal fluid.
