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Beta-lactamase induction antagonizes beta-lactam susceptibilities in Citrobacter diversus and Enterobacter cloacae
B Oliva1, T Taraborelli, N Franceschini
1Dept. of Experimental Medicine and Sciences, University of L'Aquila, Italy.
Journal of Chemotherapy (Florence, Italy)
|December 1, 1991
Abstract:
Inducible beta-lactamases were obtained after exposure to several beta-lactams in clinical isolates of Enterobacter cloacae and Citrobacter diversus. Enzyme production was related to the inducer and medium composition. beta-lactamase is able to inactivate only labile compounds, thus generating minimum inhibitory concentrations higher than in the absence of the inducer; imipenem susceptibilities usually were not changed.