Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inebilizumab in AQP4-Ab-positive neuromyelitis optica spectrum disorder.

Drugs of today (Barcelona, Spain : 1998)·2021
Same author

The ACROSS study: Long-term efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis.

Multiple sclerosis journal - experimental, translational and clinical·2020
Same author

Vemurafenib and cobimetinib combination therapy for BRAFV600E-mutated melanoma favors posterior reversible encephalopathy syndrome.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

Evidence for a white matter lesion size threshold to support the diagnosis of relapsing remitting multiple sclerosis.

Multiple sclerosis and related disorders·2019
Same author

[New aspects of immunotherapy in multiple sclerosis].

Der Nervenarzt·2018
Same author

ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis.

European journal of neurology·2018

Related Experiment Video

Updated: Jul 8, 2026

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

New developments in understanding and treating neuroinflammation.

C Infante-Duarte1, S Waiczies, J Wuerfel

  • 1Cecilie Vogt Clinic for Neurology in the HELIOS Clinic Berlin-Buch, Charité-Universitaetsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Journal of Molecular Medicine (Berlin, Germany)
|January 16, 2008
PubMed
Summary
This summary is machine-generated.

Neuroinflammation significantly impacts neurodegenerative diseases like Alzheimer's and Parkinson's, shifting neuropathology research. Understanding these links is crucial for developing advanced diagnostics and effective therapies.

More Related Videos

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
06:43

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

Published on: March 29, 2017

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity
07:31

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Published on: August 23, 2022

Related Experiment Videos

Last Updated: Jul 8, 2026

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
06:43

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

Published on: March 29, 2017

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity
07:31

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Published on: August 23, 2022

Area of Science:

  • Neuropathology
  • Neuroinflammation
  • Neurodegenerative Diseases

Background:

  • Neuroinflammatory diseases like meningitis and multiple sclerosis (MS) exhibit neurodegeneration.
  • Inflammation demonstrably affects the disease course of Alzheimer's disease (AD), Parkinson's disease (PD), and stroke.

Purpose of the Study:

  • To analyze inflammatory and degenerative pathological brain mechanisms.
  • To emphasize classical chronic inflammatory diseases, specifically MS.
  • To highlight the impact of new insights on research and therapy development.

Main Methods:

  • Review of current literature on neuropathology.
  • Analysis of inflammatory and degenerative mechanisms in the brain.
  • Focus on pathomechanistic pathways in MS.

Main Results:

  • A paradigm shift in neuropathology is occurring, integrating neuroinflammation into degenerative disease understanding.
  • Inflammatory processes are integral to the pathogenesis of AD, PD, and stroke.
  • Advanced research technologies are necessitated by new pathomechanistic insights.

Conclusions:

  • The interplay between inflammation and degeneration requires novel research approaches.
  • Understanding these mechanisms is key for developing and monitoring new therapeutic tools for brain diseases.
  • This review underscores the critical role of neuroinflammation in a broader spectrum of neurological disorders.