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Related Experiment Video

Updated: Jul 8, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
09:09

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

Infection rates and healing using bone wax and a soluble polymer material.

Tadeusz Wellisz1, Yuehuei H An, Xuejun Wen

  • 1Division of Plastic and Reconstructive Surgery, the Department of Neurosurgery, University of Southern California, 536 S Rimpau Blvd, Los Angeles, CA 90020, USA. tadeusz@wellisz.com

Clinical Orthopaedics and Related Research
|January 16, 2008
PubMed
Summary

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A new water-soluble polymer bone hemostatic material showed promise in reducing bone infections in a rabbit model. Compared to bone wax, the polymer significantly decreased osteomyelitis rates, offering a safer alternative for bone healing.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Infectious Disease Research

Background:

  • Bone hemostatic materials are crucial in surgery to control bleeding.
  • Traditional materials like bone wax can be associated with complications, including infection.
  • Novel water-soluble polymers offer potential advantages as hemostatic agents.

Purpose of the Study:

  • To evaluate the efficacy of a novel water-soluble polymer bone hemostatic material.
  • To compare infection rates and bone healing in a contaminated environment using the polymer versus bone wax.
  • To assess the safety and performance of the polymer in a rabbit tibial defect model.

Main Methods:

  • A rabbit tibial defect model was utilized with 24 rabbits.
  • Defects were treated with the water-soluble polymer, bone wax, or left untreated (control).

Related Experiment Videos

Last Updated: Jul 8, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
09:09

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

  • All defects were inoculated with Staphylococcus aureus to simulate a contaminated environment.

    • Main Results:

    • Bone wax treatment resulted in 100% infection and osteomyelitis with no bone healing.
    • The polymer and control groups showed a 25% osteomyelitis rate and 75% normal bone healing.
    • The polymer group exhibited significantly lower osteomyelitis and positive culture rates than the bone wax group.

    Conclusions:

    • The water-soluble polymer demonstrated a reduced rate of osteomyelitis compared to bone wax in a contaminated setting.
    • No significant difference in infection or healing was observed between the polymer and control groups.
    • This soluble polymer represents a potentially safer alternative to bone wax, possibly decreasing postoperative bone infections.