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Related Concept Videos

Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
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Published on: January 13, 2019

DNA data sharing: research participants' perspectives.

Amy L McGuire1, Jennifer A Hamilton, Rebecca Lunstroth

  • 1Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas 77030, USA. amcguire@bcm.edu

Genetics in Medicine : Official Journal of the American College of Medical Genetics
|January 17, 2008
PubMed
Summary
This summary is machine-generated.

Participants in genetic studies want to be informed about data sharing and prefer fewer options for consent. Explicit consent is crucial for public release of genomic information from existing samples.

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Area of Science:

  • Genomics
  • Bioethics
  • Informed Consent

Background:

  • Current genomic research policies mandate public data release with specific consent.
  • Informed consent processes often lack details on data sharing, necessitating model language.
  • Participant attitudes and judgments are vital for developing effective data sharing consent.

Purpose of the Study:

  • To describe research participants' attitudes and judgments regarding genomic data release.
  • To understand participant preferences for control over data sharing decision-making.

Main Methods:

  • Focus group sessions conducted with patients and controls.
  • Participants were drawn from a genetic study focused on epilepsy.

Main Results:

  • Participants generally desired information and decision-making control over data sharing.
  • Fewer data sharing options increased the likelihood of consent for public release.
  • Most participants believed explicit consent was necessary for public release of genomic information from existing samples.

Conclusions:

  • Informed consent for genetic research must include specific details on data sharing.
  • While participants prefer multiple release options, the impact on public release consent requires further study.