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Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Activation and functionalization of benzylic derivatives by palladium catalysts
Benoît Liégault1, Jean-Luc Renaud, Christian Bruneau
1Sciences Chimiques de Rennes, UMR 6226, Catalyse et Organométalliques, Université de Rennes 1, Campus de Beaulieu, 35042 Rennes Cedex, France.
Abstract:
Palladium-catalyzed transformations of aryl halides and pseudo-halides involving carbonylation, carbon-carbon and carbon-heteroatom bond-forming reactions, etc. are very well documented, and have already been reviewed several times. The metal-catalyzed activation of benzylic derivatives is much less described. However, during the last decades, a number of papers have shown the interest offered by benzylic derivatives (halides, carbonates, acetates, phosphonates) in selective catalytic reactions for organic synthesis, most of them in the presence of palladium catalysts. The purpose of this tutorial review is to highlight selected examples of palladium-catalyzed transformations involving reactive benzylic derivatives.
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