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Updated: Jul 8, 2026

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Simplified rat lung transplantation by using a modified cuff technique.

Wei Zhai1, Jing Ge, Ilhan Inci

  • 1Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Avenue #1277, Wuhan, China. zhaiwei720308@hotmail.com

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
|January 17, 2008
PubMed
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A simplified cuff technique significantly reduces anastomosis time in rat lung transplantation (LT). This novel method is safe, reproducible, and avoids complications, improving assessment in LT models.

Area of Science:

  • Surgical Innovation
  • Transplantation Research
  • Animal Models

Background:

  • Mizuta's cuff technique for rat lung transplantation (LT) presents challenges including vessel/bronchus twisting and extended procedure times.
  • These complications can hinder the anastomosis process in LT models.

Purpose of the Study:

  • To evaluate the advantages of a simplified cuff technique in rat LT.
  • To compare anastomosis times between the traditional and simplified methods.

Main Methods:

  • Two groups of rat orthotopic left lung transplants were compared: Group I (Mizuta's technique, n=50) and Group II (simplified modified cuff technique, n=48).
  • Anastomosis time was the primary metric for comparison.

Main Results:

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Last Updated: Jul 8, 2026

Orthotopic Left Lung Transplantation in Rats
08:22

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

A Rat Lung Transplantation Model of Warm Ischemia/Reperfusion Injury: Optimizations to Improve Outcomes
07:37

A Rat Lung Transplantation Model of Warm Ischemia/Reperfusion Injury: Optimizations to Improve Outcomes

Published on: October 28, 2021

  • The simplified technique achieved a 100% success rate with no observed twists, bleeding, or air leakage.
  • Anastomosis time was significantly reduced in Group II (11.2 ± 2.1 min) compared to Group I (18.1 ± 3.6 min, p < .01).

Conclusions:

  • The simplified cuff technique offers a faster, safer, and more reproducible approach to anastomosis in rat LT.
  • This technique minimizes complications and enhances the precision of assessments in LT research models.