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Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...

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Related Experiment Video

Updated: Jul 8, 2026

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
06:03

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Gene expression in pulmonary fibrosis.

Eileen Hsu1, Hidekata Yasuoka, Carol A Feghali-Bostwick

  • 1Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Critical Reviews in Eukaryotic Gene Expression
|January 17, 2008
PubMed
Summary

Pulmonary fibrosis, a lung disease, involves complex gene regulation. Understanding these mechanisms offers new therapeutic targets for treating this condition.

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Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Related Experiment Videos

Last Updated: Jul 8, 2026

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
06:03

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Area of Science:

  • Pulmonary medicine
  • Molecular biology
  • Genetics

Background:

  • Pulmonary fibrosis is a serious lung condition with high morbidity and mortality.
  • Current treatments for pulmonary fibrosis are limited, driving research for effective therapies.

Purpose of the Study:

  • To review and highlight gene expression regulatory mechanisms in pulmonary fibrosis.
  • To identify potential pathogenic mechanisms at multiple levels of gene regulation.

Main Methods:

  • Review of existing literature on gene expression regulation in pulmonary fibrosis.
  • Analysis of genetic, transcriptional, posttranscriptional, translational, posttranslational, and epigenetic factors.

Main Results:

  • Pulmonary fibrosis arises from abnormal gene expression due to genetic and environmental factors.
  • These alterations lead to increased extracellular matrix components like collagen and fibronectin, causing fibrosis.
  • Multiple regulatory levels, including epigenetic mechanisms, contribute to disease development.

Conclusions:

  • Understanding gene regulation in pulmonary fibrosis is crucial for developing effective treatments.
  • Identifying key mechanisms can reveal new therapeutic targets for lung fibrosis.