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Recent advances in asthma genetics
Jian Zhang1, Peter D Paré, Andrew J Sandford
1James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul's Hospital, Vancouver, B,C,, V6Z 1Y6, Canada.JZhang1@mrl.ubc.ca
Respiratory Research
|January 17, 2008
Summary
Identifying asthma susceptibility genes requires replication and functional data. This review highlights 22 additional genes with functional information, building upon previous research on genetic associations for asthma.
Area of Science:
- Genetics
- Immunology
- Respiratory Medicine
Background:
- Over 100 genes linked to asthma phenotypes, with 53 novel associations reported in 2006-2007.
- Replication and functional data are crucial for confirming asthma susceptibility genes.
- Previous reviews identified functional data for 40 polymorphisms; this work adds 22 more.
Purpose of the Study:
- To review and present functional information for additional candidate genes associated with asthma.
- To consolidate current knowledge on genes with both replicated genetic associations and demonstrated functional mechanisms for asthma.
Main Methods:
- Literature review of genetic association studies for asthma.
- Identification and compilation of studies reporting functional data for candidate asthma genes.
- Focus on genes with replicated associations and supporting functional evidence.
Main Results:
- 22 new genes with reported functional data for asthma-associated polymorphisms are identified.
- Key genes like filaggrin, interleukin-13, interleukin-17, and cysteinyl leukotriene receptor-1 are discussed.
- These genes show replicated associations and possess functional data supporting their role in asthma.
Conclusions:
- The number of asthma-associated genes with functional data continues to grow.
- Functional validation is essential for understanding the genetic basis of asthma.
- This review provides updated information on key genes contributing to asthma susceptibility.
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